Natriuretic peptide system in human heart failure.

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Natriuretic peptide system in human heart failure.

BACKGROUND Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) are a family of structurally related peptides that participate in the integrated control of renal and cardiovascular function. Previous studies suggest a functional role for these hormonal peptides in cardiorenal regulation in congestive heart failure (CHF). METHODS AND RESULTS T...

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Role of the natriuretic peptide system in heart failure pathophysiology

A recent review has shown the prevalence of heart failure in Australia to be 1-2%, similar to data obtained in Europe and North America, where prevalence rates of 1.3-2.2% have been reported. The Australian review found heart failure prevalence to be at least three times higher in the elderly compared with the general population. A statistical report from the American Heart Association notes th...

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Natriuretic peptide testing in heart failure.

Case presentation 1: A 78-year-old woman with a history of morbid obesity, coronary artery disease, chronic obstructive pulmonary disease, and chronic kidney disease (serum creatinine 2.0 mg/dL) presented to the emergency department with worsening dyspnea. Her ECG shows no acute ischemic changes; her chest radiograph reveals chronic emphysematous changes with mild bilateral infiltrates. Her lun...

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Natriuretic Peptide-guided therapy for heart failure.

Chronic heart failure (HF) remains a major medical problem in the developed world, with rapidly rising prevalence, substantial morbidity, and high costs. The concept of titrating chronic HF therapies using physiologic markers, so called "biomarker guided therapy (BGT)", has become an area of substantial interest in HF given the underutilization of evidence-based medications and suboptimal outco...

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ژورنال

عنوان ژورنال: Circulation

سال: 1993

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.88.3.1004